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KMID : 0370219870310050273
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Yakhak Hoeji
1987 Volume.31 No. 5 p.273 ~ p.279
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The Effects of Organic Acidic Drugs on the Absorption, Excretion and Diuretic Action of Furosemide
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염윤희/Yeom YH
용재익/Yong JI
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Abstract
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The effects of organic acidic drugs on the absorption, excretion and diuretic action of furosemide were studied. Cefalexin, p-aminohippuric acid (PAH), ibuprofen and p-aminosalicylic acid (PAS) were selected as organic acidic drugs. The in situ absorption rate and absorption rate constant of furosemide (30mcM) were significantly (p<0.05) decreased by 3OmcM of cefalexin, PAH, ibuprofen and PAS in rat small intestine. The plasma concentration of furosemide was significantly (p<0.01) increased by cefalexin, PAH and ibuprofen in rabbits. But the urinary excretion rate, renal clearance and diuretic action of furosemide were significantly (p<0.05) decreased by cefalexin, PAH, ibuprofen and PAS in rabbits.
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KEYWORD
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